Synthetic strategies toward 1,3-oxathiolane nucleoside analogues

• Umesh P. Aher,
• Dhananjai Srivastava,
• Girij P. Singh and
• Jayashree B. S

Beilstein J. Org. Chem. 2021, 17, 2680–2715, doi:10.3762/bjoc.17.182

• the logic while depicting comparison with the established series of nucleoside analogues. In chiral synthesis, it is often important to establish the ratio of enantiomers before focusing on the isolation of a specific enantiomer. Therefore, having a good overview on enzymatic and chemical resolution

Recent advances in hypervalent iodine(III)-catalyzed functionalization of alkenes

• Xiang Li,
• Pinhong Chen and
• Guosheng Liu

Beilstein J. Org. Chem. 2018, 14, 1813–1825, doi:10.3762/bjoc.14.154

• reagents in chiral synthesis. As outlined, there have been achieved great advances in the hypervalent iodine-mediated functionalization of alkenes. However, the types of chiral iodoarene catalysts are limited and new chiral iodoarene scaffolds should be developed for highly stereoselective reactions

P(O)R₂-directed Pd-catalyzed C–H functionalization of biaryl derivatives to synthesize chiral phosphorous ligands

• Rong-Bin Hu,
• Hong-Li Wang,
• Hong-Yu Zhang,
• Heng Zhang,
• Yan-Na Ma and
• Shang-dong Yang

Beilstein J. Org. Chem. 2014, 10, 2071–2076, doi:10.3762/bjoc.10.215

• products are produced with good enantioselectivity. Keywords: chiral synthesis; Pd-catalysis; organophosphorus; phosphorus ligands; P(O)R2-directing; Introduction In the past decades, phosphorus ligands have been demonstrated to be efficient ligands in many metal-catalyzed organic reactions [1][2][3][4

Approaches to α-amino acids via rearrangement to electron-deficient nitrogen: Beckmann and Hofmann rearrangements of appropriate carboxyl-protected substrates

• Sosale Chandrasekhar and
• V. Mohana Rao

Beilstein J. Org. Chem. 2012, 8, 1393–1399, doi:10.3762/bjoc.8.161

• challenges regarding chiral synthesis. The challenges in the synthesis of α-amino acids essentially stem from the fact that the methods which are normally employed for the independent synthesis of the carboxyl and amine functionalities, are often mutually incompatible. Thus, for example, the oxidation of

Towards racemizable chiral organogelators

• Jian Bin Lin,
• Debarshi Dasgupta,
• Seda Cantekin and
• Albertus P. H. J. Schenning

Beilstein J. Org. Chem. 2010, 6, 960–965, doi:10.3762/bjoc.6.107

• advanced materials and constrained media for chiral synthesis and separation [3][4][5]. The development of systems where the chiral supramolecular assembly responds to specific triggers, should facilitate the design of smart functional materials in which subtle molecular-scale changes have an impact on the